[HTML][HTML] Deficiency of liver Comparative Gene Identification-58 causes steatohepatitis and fibrosis in mice
F Guo, Y Ma, AKG Kadegowda, JL Betters, P Xie… - Journal of lipid …, 2013 - ASBMB
Triglyceride (TG) accumulation in hepatocytes (hepatic steatosis) preludes the development
of advanced nonalcoholic fatty liver diseases (NAFLDs) such as steatohepatitis, fibrosis, and
cirrhosis. Mutations in human Comparative Gene Identification-58 (CGI-58) cause cytosolic
TG-rich lipid droplets to accumulate in almost all cell types including hepatocytes. However,
it is unclear if CGI-58 mutation causes hepatic steatosis locally or via altering lipid
metabolism in other tissues. To directly address this question, we created liver-specific CGI …
of advanced nonalcoholic fatty liver diseases (NAFLDs) such as steatohepatitis, fibrosis, and
cirrhosis. Mutations in human Comparative Gene Identification-58 (CGI-58) cause cytosolic
TG-rich lipid droplets to accumulate in almost all cell types including hepatocytes. However,
it is unclear if CGI-58 mutation causes hepatic steatosis locally or via altering lipid
metabolism in other tissues. To directly address this question, we created liver-specific CGI …
